Brief Communication Structural Basis of Swinholide A Binding to Actin
نویسندگان
چکیده
Vadim A. Klenchin,1 Ryan King,1 Junichi Tanaka,2,3 Gerard Marriott,2 and Ivan Rayment1,* 1Department of Biochemistry University of Wisconsin at Madison 433 Babcock Drive Madison, Wisconsin 53706 2Department of Physiology University of Wisconsin at Madison 1300 University Avenue Madison, Wisconsin 53706 3Department of Chemistry, Biology, and Marine Science University of the Ryukyus Nishihara, Okinawa 903-0213 Japan
منابع مشابه
Structural basis of swinholide A binding to actin.
Marine toxins targeting the actin cytoskeleton represent a new and promising class of anti-cancer compounds. Here we present a 2.0 A resolution structure of swinholide A, a marine macrolide, bound to two actin molecules. The structure demonstrates that the actin dimer in the complex does not represent a physiologically relevant entity, for the two actin molecules do not interact with each other...
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